Snap-8 is a synthetic linear octapeptide engineered as a bioactive anti-aging ingredient for cosmetic applications. Produced via solid-phase peptide synthesis, it features an acetylated N-terminus and amidated C-terminus for enhanced metabolic stability and cell membrane penetration. The 8-amino acid sequence mimics the active domain of botulinum toxin A but with significantly lower molecular weight (~1kDa vs. 150kDa), enabling topical absorption without injection. Its thiol group (methionine residue) contributes to conformational stability, while the arginine-arginine motif enhances水溶性 (soluble in H₂O/DMSO at >10mg/ml). As a cosmetic-grade peptide, it is non-toxic, non-irritating, and free from animal-derived components, complying with EU Cosmetics Regulation (EC) No 1223/2009.
⚙️ Mechanism of Action
SNARE Complex Inhibition: Competes with SNAP-25 (synaptosomal-associated protein 25) for binding sites on the SNARE complex, blocking acetylcholine vesicle fusion with presynaptic membranes. This reduces neurotransmitter release at neuromuscular junctions by ~30-40% in in vitro models, analogous to botulinum toxin but with reversible, dose-dependent effects.
Muscle Contraction Modulation: Decreases microcontractions of facial mimic muscles (orbicularis oculi, frontalis) by targeting peripheral nerve endings, preventing the formation of dynamic wrinkles (crow’s feet, forehead lines) and softening existing static wrinkles.
Collagen Stimulation: Upregulates fibroblasts to increase type I and III collagen synthesis by 20-25% after 4 weeks of topical application, as demonstrated in human dermal explant studies.
Anti-Inflammatory Activity: Inhibits NF-κB pathway activation and reduces IL-6/IL-8 cytokine release in UV-irradiated keratinocytes, mitigating photoaging-related inflammation.
📊 Cosmetic Applications
Anti-Wrinkle Formulations: Key ingredient in luxury skincare products targeting facial expression lines (concentration: 0.01-0.5% in serums, creams, and masks). Clinical trials show 27% reduction in wrinkle depth and 35% improvement in skin smoothness after 28 days of twice-daily application.
Preventative Aging: Used in eye creams and neck treatments to delay wrinkle formation in individuals aged 25-40 with incipient signs of aging.
Post-Procedure Care: Included in post-filler or laser treatment products to maintain results and minimize muscle tension-induced complications.
Makeup Primers: Added to cosmetic bases (0.05-0.1%) to provide immediate skin-smoothing effects and enhance foundation adherence.
💡 Product Features
Bioavailability: Superior skin penetration compared to larger peptides; reaches epidermal-dermal junction within 2 hours of topical application (confocal microscopy data).
Stability Profile: Stable at pH 5.0-7.0; recommended incorporation at temperatures <40°C to prevent peptide degradation. Compatible with common cosmetic ingredients (hyaluronic acid, retinol, vitamin C derivatives).
Synergistic Effects: Combinations with matrixyl 3000 (palmitoyl tripeptide-1 + palmitoyl tetrapeptide-7) show additive anti-aging benefits, increasing collagen production by 45% vs. single peptides.
Safety Data: Ames test negative for mutagenicity; human patch testing with 1% concentration shows no erythema or sensitization in 500 subjects.
💼 Commercial Specifications
Manufacturing: GMP-certified production facilities; batch-to-batch consistency ensured by HPLC and mass spectrometry quality control.
Packaging: Nitrogen-flushed aluminum foil bags or glass vials with desiccant; shelf life ≥24 months when stored at -20°C away from light.
Global Supply: Available from specialized peptide manufacturers (China, Europe, USA) with minimum order quantities of 1g and bulk production capacity up to 100kg/month.
Regulatory Status: Listed in CosIng (EU Cosmetics Ingredients Database) and compliant with FDA CFR Title 21 for cosmetic use.
None of our HGH lines are inherently better than the other. Each batch comes with a corresponding test report. Purity and dimer can be a decent proxy for “quality”, you want purity as high as possible and dimer as low as possible. The main factor to consider in our opinion, is the price per IU. Supreme is usually the best bang for buck option. Historically, Supreme & Deluxe have shown lower dimer content, although this may not always be the case, so of course reference the corresponding test reports.
For HGH, we typically recommend 1ml for every ~10 IU in the vial. If a batch tests at an average of 290 IU per kit, that is an average of 29 IU per vial, and we’d recommend 2.9ml of bacteriostatic water. This will make the syringe math similar to a traditional 100 iu kit with 1ml of solution For peptide reconstituion, you can use our amazing Dosage Calculator.
Not necessarily. If you look through all our lab reports, particularly the ones with multiple test reports in a single batch, you will see that the intra-batch variance can actually be quite high. When you purchase a batch, you can expect some of the vials in your kit to be as much as 5-15% +/- whatever the corresponding lab test reflects. This is simply the reality of product that is not made to the same standards as pharmaceutical grade growth hormone. To state otherwise would be disingenous. There can also be a high variance in the dimer content intra-batch. (For Example: Economy B, Deluxe A, etc) Over time, we’ve increased the volume of samples analyzed for each batch, to provide more transparancy regarding the potential for intra-batch variance. If you use the average IU figure provided on each product, your dosage should average out over time, so don’t overthink your administration protocol too much. We know it can be a bit overwhelming with all the different numbers provided. That said, don’t hesitate to reach out if you need specific guidance on dosage or reconstitution.
Yes! We offer store credit for quantitative testing of total IU/Purity (ie Janoshik testing), and for personal IGF-1 test results. Please email for more information. *TERMS APPLY*
Depending on your location, most customers receive their order in 2-10 business days. We ship with USPS Ground Shipping, from the United States only. 99% of orders ship within 24 hours (excluding weekends & holidays)
We are no longer providing tracking. If your order is over 10 business days old and hasn’t arrived, our customer service team can check your tracking information to see the status of your package
If your order was marked as “completed”, typically this means a label has been generated and your order is scheduled to go out that day or the next. “Processing” status orders have not been shipped, processing means payment has been confirmed successfully. Don’t hesitate to reach out regarding the status of your order.
Unfortunately we do not provide reships for incorrect addresses. In the VERY rare instance that a package is lost in transit, we will reship your order free of charge.
Tirzepatide is a cutting-edge dual incretin agonist that mimics both GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) — two key hormones involved in regulating blood sugar, satiety, and energy balance. This unique mechanism allows for enhanced appetite suppression, improved insulin sensitivity, and significant fat loss when combined with proper nutrition and lifestyle protocols.
Available as a lyophilized powder, Tirzepatide requires reconstitution prior to use.
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MOTS-c is a naturally occurring mitochondrial-derived peptide that plays a key role in cellular energy regulation, fat metabolism, and glucose control. Often referred to as a “metabolic mini-hormone,” MOTS-c enhances the body’s ability to burn fat, improve insulin sensitivity, and adapt to metabolic stress — making it an ideal peptide for those seeking fat loss, improved endurance, and anti-aging support.
This product is supplied as a lyophilized powder and requires reconstitution prior to subcutaneous injection.
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TB-500 is a synthetic version of Thymosin Beta-4, a naturally occurring peptide involved in tissue regeneration and healing. Known for its ability to promote cell migration, reduce inflammation, and accelerate soft tissue repair, TB-500 is widely used in recovery protocols for muscle strains, joint issues, and connective tissue healing.
This package includes 10 vials, each containing 10mg of lyophilized TB-500, ideal for multi-week recovery or performance programs.
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