Sermorelin is a synthetic polypeptide corresponding to the biologically active N-terminal 29-amino acid fragment of human growth hormone-releasing hormone (GHRH). As the shortest fully functional GHRH analog, it retains the native hormone’s ability to stimulate growth hormone (GH) secretion while offering improved stability and bioavailability compared to full-length GHRH. Its structure includes a methionine residue (position 27) and amidated C-terminus, critical for receptor binding and resistance to enzymatic degradation.
⚙️ Mechanism of Action
GHRH Receptor Activation: Binds to GHRH receptors on pituitary somatotrophs, triggering cyclic AMP (cAMP) signaling and calcium influx to stimulate pulsatile GH release.
GH/IGF-1 Axis Modulation: Induces physiological GH secretion patterns, leading to downstream increases in insulin-like growth factor-1 (IGF-1) synthesis in the liver and peripheral tissues.
Immunomodulatory Effects: Enhances non-specific immune function by increasing thymus/spleen weight, promoting T-lymphocyte proliferation, and improving macrophage phagocytic activity in preclinical models.
Growth Hormone Secretagogue Synergy: Acts additively with GHRPs (e.g., Ipamorelin) to amplify GH release by counteracting somatostatin inhibition.
📊 Research Applications
Endocrinology: Studies on GH deficiency, pituitary function, and somatotropic axis regulation.
Diagnostic Research: Used as a provocative agent to evaluate GH reserve in growth disorder models.
Immunology: Investigation of neuroendocrine-immune network interactions and immunomodulatory therapies.
Anti-Aging Research: Evaluation of age-related GH decline and potential interventions for sarcopenia or metabolic frailty.
💡 Product Features
Physiological Pulsatility: Mimics endogenous GH secretion patterns, avoiding receptor desensitization seen with continuous GH administration.
Stability: Lyophilized form stable for 24 months at -20°C; reconstitutes in aqueous solvents (e.g., sterile saline) with refrigerated stability for 7-14 days.
Selectivity: Minimal cross-reactivity with other hypothalamic-pituitary hormones (e.g., ACTH, prolactin), ensuring focused GH axis modulation.
Purity: ≥98% HPLC purity with low endotoxin levels, suitable for in vitro, ex vivo, and preclinical in vivo studies.
⚠️ Disclaimer
For Research Use Only: Not approved for human or veterinary clinical applications. Handling requires compliance with peptide research protocols, including proper storage, reconstitution, and biosafety measures.
None of our HGH lines are inherently better than the other. Each batch comes with a corresponding test report. Purity and dimer can be a decent proxy for “quality”, you want purity as high as possible and dimer as low as possible. The main factor to consider in our opinion, is the price per IU. Supreme is usually the best bang for buck option. Historically, Supreme & Deluxe have shown lower dimer content, although this may not always be the case, so of course reference the corresponding test reports.
For HGH, we typically recommend 1ml for every ~10 IU in the vial. If a batch tests at an average of 290 IU per kit, that is an average of 29 IU per vial, and we’d recommend 2.9ml of bacteriostatic water. This will make the syringe math similar to a traditional 100 iu kit with 1ml of solution For peptide reconstituion, you can use our amazing Dosage Calculator.
Not necessarily. If you look through all our lab reports, particularly the ones with multiple test reports in a single batch, you will see that the intra-batch variance can actually be quite high. When you purchase a batch, you can expect some of the vials in your kit to be as much as 5-15% +/- whatever the corresponding lab test reflects. This is simply the reality of product that is not made to the same standards as pharmaceutical grade growth hormone. To state otherwise would be disingenous. There can also be a high variance in the dimer content intra-batch. (For Example: Economy B, Deluxe A, etc) Over time, we’ve increased the volume of samples analyzed for each batch, to provide more transparancy regarding the potential for intra-batch variance. If you use the average IU figure provided on each product, your dosage should average out over time, so don’t overthink your administration protocol too much. We know it can be a bit overwhelming with all the different numbers provided. That said, don’t hesitate to reach out if you need specific guidance on dosage or reconstitution.
Yes! We offer store credit for quantitative testing of total IU/Purity (ie Janoshik testing), and for personal IGF-1 test results. Please email for more information. *TERMS APPLY*
Depending on your location, most customers receive their order in 2-10 business days. We ship with USPS Ground Shipping, from the United States only. 99% of orders ship within 24 hours (excluding weekends & holidays)
We are no longer providing tracking. If your order is over 10 business days old and hasn’t arrived, our customer service team can check your tracking information to see the status of your package
If your order was marked as “completed”, typically this means a label has been generated and your order is scheduled to go out that day or the next. “Processing” status orders have not been shipped, processing means payment has been confirmed successfully. Don’t hesitate to reach out regarding the status of your order.
Unfortunately we do not provide reships for incorrect addresses. In the VERY rare instance that a package is lost in transit, we will reship your order free of charge.
Master Antioxidant | Detoxification, Immune Support, and Cellular Health
Glutathione is the body’s primary intracellular antioxidant, essential for protecting cells from oxidative stress, supporting liver detoxification, and maintaining immune resilience. This formulation provides high-purity, pharmaceutical-grade Glutathione, packaged as 10 x 600mg lyophilized vials, intended for intramuscular (IM) use after reconstitution.
Widely used in wellness, recovery, and anti-aging protocols, Glutathione plays a central role in cellular repair and defense.
Human Chorionic Gonadotropin | Hormonal Support for Testosterone Optimization & Fertility
Overview:
HCG (Human Chorionic Gonadotropin) is a peptide hormone that mimics LH (luteinizing hormone), stimulating the testes to produce natural testosterone and support spermatogenesis. It’s widely used in TRT (Testosterone Replacement Therapy) to preserve fertility, maintain testicular volume, and prevent shutdown of endogenous testosterone production.
Each vial contains 5000 IU of lyophilized HCG powder, requiring reconstitution before use. 10 vials per kit.
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This product has multiple variants. The options may be chosen on the product page
