Mesterolone-10mg Product Introduction
Mesterolone-10mg, the main ingredient of which is mesterolone, is chemically called 1α-methyl-dihydrotestosterone, and is a synthetic androgen drug. With its unique androgenic activity and relatively mild metabolic characteristics, it occupies a place in the field of male disease treatment and male health maintenance, but it is necessary to strictly follow medical guidance when using it and be alert to potential risks.
I. Basic characteristics
(I) Composition and structure
The chemical formula of mesterolone is C₂₀H₃₂O. Its chemical structure has been modified on the basis of testosterone. The introduction of 1α-methyl makes it more oral active and not easily metabolized and decomposed by the liver. This structural characteristic enables mesterolone to stably exert its androgenic effect, and compared with other androgenic drugs, it has relatively low toxicity to the liver, reducing the risk of liver damage during medication.
(II) Dosage form and specifications
The common dosage form is a white oral tablet, each tablet contains exactly 10mg mesterolone. This dosage form is easy for patients to swallow, and the 10mg single-tablet dosage design allows doctors to flexibly formulate personalized medication plans based on the patient’s specific condition and physical condition. The packaging specifications are mostly 30 tablets/box or 50 tablets/box. When storing, it needs to be kept away from light, sealed, and placed in a cool and dry place to prevent the drug from being damp and oxidized and becoming ineffective.
(III) Mechanism of action
After entering the human body, mesterolone can bind tightly to androgen receptors to form a hormone-receptor complex. This complex enters the cell nucleus, binds to specific regions on DNA, regulates gene expression, and thus exerts a series of androgen-like effects. On the one hand, it can promote protein synthesis, increase the uptake of amino acids by muscle cells, accelerate muscle protein synthesis, and help improve muscle mass and strength; on the other hand, mesterolone can stimulate erythropoiesis, increase hemoglobin levels, enhance the body’s oxygen carrying capacity, and improve physical endurance. In addition, in the male reproductive system, it can also regulate the hypothalamus-pituitary-gonadal axis, promote sperm production, and maintain normal reproductive function.
II. Clinical application
(I) Treatment of male hypogonadism
Applicable population: Applicable to male patients with insufficient androgen secretion due to various reasons, such as congenital testicular dysgenesis, acquired testicular damage, hypopituitarism, etc. These patients often show symptoms such as decreased libido, erectile dysfunction, poor development of secondary sexual characteristics, muscle atrophy, fatigue and weakness.
Therapeutic effect: By supplementing mesterolone, the androgen level in the patient’s body can be effectively increased, sexual desire and sexual function can be improved, and the hardness and durability of erection can be enhanced; the development of secondary sexual characteristics, such as increased hair and thicker voice, can be promoted; muscle mass and strength can be increased, the body’s metabolic rate can be improved, and fatigue symptoms can be relieved. Long-term standardized treatment can help patients restore normal physiological and living conditions and improve their quality of life.
Usage: When treating male hypogonadism, the recommended initial dose is 25-50mg per day, taken orally in 1-2 times. The doctor will gradually adjust the dosage during the medication process according to the patient’s testosterone level, symptom improvement and individual differences. The maintenance dose is usually about 25mg per day. During treatment, testosterone, liver function, blood lipids and other indicators need to be monitored regularly to evaluate the treatment effect and safety.
(II) Auxiliary treatment of oligospermia and asthenospermia
Applicable population: For male infertility patients with abnormal semen quality, such as low sperm count and low motility, after excluding other clear causes, mesterolone can be used for auxiliary treatment. These patients may have abnormal sperm production and development due to insufficient androgen levels or spermatogenic dysfunction.
Therapeutic effect: mesterolone can regulate the reproductive endocrine environment, promote the production and maturation of sperm in the testicles, and increase the number and motility of sperm. Clinical studies have shown that after a period of treatment with mesterolone, some patients have significantly improved semen quality and increased the chance of natural conception. However, it should be noted that mesterolone usually needs to be used in combination with other drugs, and the treatment cycle is relatively long, generally 3-6 months.
Usage: In the auxiliary treatment of oligospermia and asthenospermia, the dosage is usually 25-50mg per day, taken orally in 1-2 times. During the treatment, it is necessary to regularly review the semen routine, six sex hormones and other indicators, and adjust the treatment plan according to the examination results. At the same time, it is recommended that patients maintain a healthy lifestyle, such as quitting smoking and drinking, keeping a regular schedule, and exercising moderately, in order to improve the treatment effect.
(III) Improving the symptoms of androgen deficiency in middle-aged and elderly men
Applicable population: With the increase of age, the level of androgen in the body of middle-aged and elderly men gradually decreases, and a series of symptoms related to androgen deficiency may occur, such as decreased libido, decreased physical strength, mood swings, and decreased bone density. For middle-aged and elderly men with obvious symptoms and diagnosed with androgen deficiency by examination, mesterolone can be used as a treatment option.
Therapeutic effect: The use of mesterolone can supplement the insufficient androgen in the body, relieve symptoms such as decreased libido and fatigue, and improve the quality of life; enhance muscle strength and reduce muscle atrophy; improve bone metabolism, increase bone density, and reduce the risk of osteoporosis. However, middle-aged and elderly men need to carefully assess the risks and benefits when using mesterolone and pay close attention to adverse drug reactions.
Usage: For middle-aged and elderly men, the initial dose generally starts at 25 mg per day, orally. During the medication process, the patient’s reaction should be closely observed. If adverse reactions such as aggravated prostatic hyperplasia and sleep apnea syndrome occur, the dose should be adjusted or the drug should be discontinued in time. At the same time, the prostate-specific antigen (PSA) level should be monitored regularly to exclude the risk of prostate cancer.
III. Usage and Dosage
(I) Individualized Adjustment
The usage and dosage of mesterolone needs to be highly individualized. The doctor will make adjustments based on the patient’s age, cause, severity of the disease, physical condition, and response to the drug. For example, young patients may have better tolerance to the drug and the dose can be increased appropriately; while for elderly patients or patients with other chronic diseases, the dose needs to be adjusted carefully, starting from a small dose and gradually increasing to avoid adverse reactions.
(II) Strictly follow the doctor’s instructions
Patients must strictly follow the doctor’s prescription and must not increase or decrease the dose or stop the drug on their own. Randomly adjusting the dosage may lead to poor treatment effect or cause adverse reactions. If you have any discomfort or questions during medication, you should consult a doctor in time and handle it under the doctor’s guidance.
