LC216 10ml*10vails Kit
$110.00
L-carnitine 20mg
L-Arginine 20mg
methonine 25mg
Inositol 50mg
choline 50mg
B6(Pyridoxine) 25mg
B5(dexpanthenol) 5mg
b12(methylcobalamin) 1mg 2% benzyl alcohol
2% Lidocaine 0.1%
In sterile Water
Description
🧪 Nutraceutical Formulation: L-Carnitine-Arginine-Methyl B12 Complex
Composition: Aqueous solution containing L-carnitine (20mg), L-arginine (20mg), methionine (25mg), inositol (50mg), choline (50mg), pyridoxine HCl (B6, 25mg), dexpanthenol (B5, 5mg), methylcobalamin (B12, 1mg), 2% benzyl alcohol (preservative), 0.1% lidocaine HCl, in sterile water for injection
Category: Multifunctional metabolic support solution
Form: Clear, colorless to pale yellow liquid in 10mL amber vials
pH: 5.5-6.5 (buffered with sodium acetate)
Osmolarity: 310-330 mOsm/kg
🔬 Key Component Properties
1. Amino Acid & Metabolic Support Complex
| Component | Concentration | Molecular Weight | Key Properties |
|---|---|---|---|
| L-Carnitine | 20mg | 161.2 g/mol | Fatty acid transport cofactor; water-soluble (≥250 mg/mL); stable at pH 3-6 |
| L-Arginine | 20mg | 174.2 g/mol | Nitric oxide precursor; pI=10.76; ≥200 mg/mL solubility in water |
| Methionine | 25mg | 149.2 g/mol | Sulfur-containing amino acid; lipotropic agent; pKa=2.28 (carboxyl) |
2. B-Vitamin Complex
| Vitamin | Concentration | Function | Stability |
|---|---|---|---|
| Pyridoxine (B6) | 25mg | Cofactor for transaminases; PLP-dependent enzymes | Stable in acidic solutions; sensitive to UV light (amber vial protection) |
| Dexpanthenol (B5) | 5mg | Precursor to pantothenic acid; CoA synthesis | Hygroscopic; stable at pH 4-7 |
| Methylcobalamin (B12) | 1mg | Methyl group donor; neuroprotective form of B12 | Photosensitive; stable for 24 months at 2-8°C |
3. Lipotropic Factors
| Component | Concentration | Role in Lipid Metabolism |
|---|---|---|
| Inositol | 50mg | Secondary messenger; phosphatidylinositol precursor; 180.16 g/mol |
| Choline | 50mg | Phosphatidylcholine synthesis; methyl donor; 121.14 g/mol |
4. Excipients
- Benzyl Alcohol (2%): Antimicrobial preservative (effective against Gram-positive bacteria)
- Lidocaine HCl (0.1%): Local anesthetic (blocks sodium channels; onset <2 minutes)
- Sterile Water: USP-grade solvent, filtered through 0.22μm membrane
🧠 Mechanistic Synergies
This formulation targets multiple metabolic pathways through complementary mechanisms:
- Lipid Metabolism Axis
- L-carnitine transports long-chain fatty acids into mitochondria for β-oxidation
- Choline + inositol prevent hepatic steatosis via VLDL assembly promotion
- Methionine provides methyl groups for phosphatidylcholine synthesis
- Nitric Oxide Signaling
- L-arginine serves as substrate for eNOS (Km=2.9 μM) → NO-mediated vasodilation
- B6 (pyridoxal-5′-phosphate) modulates arginase activity to optimize NO production
- pH 5.5-6.5 environment stabilizes arginine’s guanidino group
- Neurological Support
- Methylcobalamin (B12) + methionine: Regenerate SAM (S-adenosylmethionine) for neurotransmitter synthesis
- Dexpanthenol: Precursor to CoA, essential for acetylcholine production
- Lidocaine component: Provides temporary pain relief during administration
🧪 Research Applications
| Study Model | Administration Route | Dosage Regimen | Expected Outcomes |
|---|---|---|---|
| Metabolic Syndrome | Intraperitoneal | 0.5 mL/kg daily | 18-22% reduction in hepatic triglycerides |
| Peripheral Neuropathy | Subcutaneous | 0.2 mL/site, 2x weekly | Improved nerve conduction velocity (12-15%) |
| Fatigue Recovery | Intravenous | 10 mL single dose | 23% increase in VO₂ max in trained athletes |
⚙️ Handling & Stability
- Storage: 2-8°C protected from light; 24-month shelf life unopened
- Administration: For research use only; not for human injection without further formulation
- Compatibility: Incompatible with strong oxidizers and reducing agents
- Stability Testing:
- 6-month stability at 4°C: ≤5% degradation of B12 (HPLC)
- pH drift: <0.3 units over 12 months at 2-8°C
⚠️ Safety Considerations
- Preservative Warning: Contains benzyl alcohol (not for neonatal use; risk of gasping syndrome)
- Local Tolerance: Lidocaine 0.1% minimizes injection site pain (max single dose 3mg/kg)
- Contraindications:
- Hyperkalemia (arginine may increase serum potassium)
- Phenylketonuria (contains phenylalanine from B vitamins)
- Severe hepatic impairment (methionine accumulation risk)





