Product Name: IGF-1LR3 (Long-R3-IGF-I, Long Chain R3 Insulin-like Growth Factor-I) CAS Number: 946870-92-4 Molecular Formula: C₃₉₀H₆₂₈N₁₁₀O₁₂₄S Molecular Weight: ~9.9 kDa (83 amino acids) Amino Acid Sequence: Modified human IGF-1 with an N-terminal 13-amino acid extension and substitution of Glu³ with Arg (R3), resulting in an 83-residue polypeptide. Purity: ≥98% (HPLC verified) / ≥90% (SDS-PAGE) Formulation: Lyophilized white powder (standard vials: 1mg, 5mg, 10mg)
🔬 Key Characteristics
IGF-1LR3 is a recombinant analog of insulin-like growth factor-1 (IGF-1) engineered for enhanced biological activity and reduced binding to IGF-binding proteins (IGFBPs). Developed in 1992, its structural modifications—an N-terminal 13-amino acid extension and Glu³→Arg substitution—significantly decrease IGFBP affinity, increasing free bioavailable concentrations by up to 10-fold compared to native IGF-1. This results in prolonged half-life and potent activation of the IGF-1 receptor (IGF-1R) in preclinical models.
⚙️ Mechanism of Action
IGF-1R Activation: Binds with high affinity to IGF-1R, triggering receptor autophosphorylation and activation of downstream signaling cascades (PI3K/AKT and MAPK pathways).
Cell Proliferation & Survival: Stimulates DNA synthesis, cell cycle progression (G1→S phase), and inhibits apoptosis via AKT-mediated suppression of pro-apoptotic proteins (e.g., Bax).
Anabolic Effects: Promotes protein synthesis, muscle hypertrophy, and bone/cartilage growth by upregulating mTORC1 signaling.
IGFBP Evasion: Reduced binding to IGFBPs (e.g., IGFBP-3) ensures sustained free ligand availability, avoiding sequestration and degradation.
📊 Research Applications
Cell Biology: In vitro studies of cell growth, differentiation, and survival (e.g., muscle satellite cells, osteoblasts, neurons).
Musculoskeletal Research: Models of muscle wasting, osteoporosis, and tissue regeneration.
Oncology: Investigation of IGF-1R signaling in cancer cell proliferation and targeted therapy development.
Metabolic Studies: Evaluation of insulin sensitivity, glucose uptake, and adipocyte metabolism.
💡 Product Features
Bioactivity: Specific activity ≥1.0×10⁶ IU/mg (FDC-P1 cell proliferation assay), with ED₅₀ ≤2.0 ng/ml.
Stability: Lyophilized form stable for 24 months at -20°C; reconstituted solutions (sterile water or PBS) stable for 2-7 days at 4°C.
Expression System: Produced in E. coli or HEK293 cells, with options for His-tagged variants for purification.
Low Cross-Reactivity: Minimal binding to insulin receptors, ensuring IGF-1R-specific signaling in research models.
⚠️ Disclaimer
For Research Use Only: Not approved for human or veterinary clinical use. Handling requires compliance with biosafety protocols for recombinant proteins, including proper reconstitution and disposal of contaminated materials.
None of our HGH lines are inherently better than the other. Each batch comes with a corresponding test report. Purity and dimer can be a decent proxy for “quality”, you want purity as high as possible and dimer as low as possible. The main factor to consider in our opinion, is the price per IU. Supreme is usually the best bang for buck option. Historically, Supreme & Deluxe have shown lower dimer content, although this may not always be the case, so of course reference the corresponding test reports.
For HGH, we typically recommend 1ml for every ~10 IU in the vial. If a batch tests at an average of 290 IU per kit, that is an average of 29 IU per vial, and we’d recommend 2.9ml of bacteriostatic water. This will make the syringe math similar to a traditional 100 iu kit with 1ml of solution For peptide reconstituion, you can use our amazing Dosage Calculator.
Not necessarily. If you look through all our lab reports, particularly the ones with multiple test reports in a single batch, you will see that the intra-batch variance can actually be quite high. When you purchase a batch, you can expect some of the vials in your kit to be as much as 5-15% +/- whatever the corresponding lab test reflects. This is simply the reality of product that is not made to the same standards as pharmaceutical grade growth hormone. To state otherwise would be disingenous. There can also be a high variance in the dimer content intra-batch. (For Example: Economy B, Deluxe A, etc) Over time, we’ve increased the volume of samples analyzed for each batch, to provide more transparancy regarding the potential for intra-batch variance. If you use the average IU figure provided on each product, your dosage should average out over time, so don’t overthink your administration protocol too much. We know it can be a bit overwhelming with all the different numbers provided. That said, don’t hesitate to reach out if you need specific guidance on dosage or reconstitution.
Yes! We offer store credit for quantitative testing of total IU/Purity (ie Janoshik testing), and for personal IGF-1 test results. Please email for more information. *TERMS APPLY*
Depending on your location, most customers receive their order in 2-10 business days. We ship with USPS Ground Shipping, from the United States only. 99% of orders ship within 24 hours (excluding weekends & holidays)
We are no longer providing tracking. If your order is over 10 business days old and hasn’t arrived, our customer service team can check your tracking information to see the status of your package
If your order was marked as “completed”, typically this means a label has been generated and your order is scheduled to go out that day or the next. “Processing” status orders have not been shipped, processing means payment has been confirmed successfully. Don’t hesitate to reach out regarding the status of your order.
Unfortunately we do not provide reships for incorrect addresses. In the VERY rare instance that a package is lost in transit, we will reship your order free of charge.
Retatrutide is a next-generation triple incretin agonist, targeting GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and Glucagon receptors simultaneously. This unique triple-action mechanism offers a powerful blend of appetite suppression, fat oxidation, and energy regulation, positioning Retatrutide at the forefront of advanced weight management and metabolic enhancement therapies.
This product is supplied as a lyophilized powder and requires reconstitution before use.
Select options
This product has multiple variants. The options may be chosen on the product page
Master Antioxidant | Detoxification, Immune Support, and Cellular Health
Glutathione is the body’s primary intracellular antioxidant, essential for protecting cells from oxidative stress, supporting liver detoxification, and maintaining immune resilience. This formulation provides high-purity, pharmaceutical-grade Glutathione, packaged as 10 x 600mg lyophilized vials, intended for intramuscular (IM) use after reconstitution.
Widely used in wellness, recovery, and anti-aging protocols, Glutathione plays a central role in cellular repair and defense.
