(CAS 89030-95-5); supplier specifications (; Pickart L et al. (1973) isolation studies; 2018 gene expression analysis in Journal of Investigative Dermatology; 2003 wound healing trials in Archives of Dermatological Research.
Product Name: GHK-Cu (Copper Tripeptide-1, Glycyl-L-Histidyl-L-Lysine Copper Complex) CAS Number: 89030-95-5 Molecular Formula: C₁₄H₂₁CuN₆O₄ Molecular Weight: 400.91 g/mol Amino Acid Sequence: Glycyl-L-Histidyl-L-Lysine (GHK) chelated with copper(II) ion [Cu²⁺] Purity: ≥98% (HPLC verified) Formulation: Lyophilized blue to purple powder (standard vials: 1mg, 5mg, 10mg; bulk quantities available)
🔬 Key Characteristics
GHK-Cu is a naturally occurring copper-peptide complex first isolated from human plasma in 1973 by Dr. Loren Pickart. Its structure consists of the tripeptide Gly-His-Lys (GHK) with high affinity for copper(II) ions, forming a stable chelate that enhances cellular recognition and absorption. The blue-purple coloration arises from the copper(II) coordination complex, while its small molecular weight (~400 Da) ensures excellent skin permeability, allowing deep penetration into the dermis to activate repair mechanisms.
⚙️ Mechanism of Action
Collagen & Extracellular Matrix Synthesis: Stimulates fibroblasts to produce collagen (types I, III, IV), elastin, and glycosaminoglycans (e.g., hyaluronic acid), enhancing skin elasticity and reducing wrinkle depth.
Antioxidant & Anti-Inflammatory Activity: Acts as a superoxide dismutase (SOD) mimic, scavenging reactive oxygen species (ROS) and inhibiting metal ion-induced lipid peroxidation. Downregulates pro-inflammatory cytokines (TNF-α, IL-6) to mitigate inflammation-related skin damage.
Cellular Regeneration: Promotes keratinocyte and fibroblast migration/proliferation, accelerating wound healing in burns, surgical incisions, and post-procedural skin recovery.
Gene Regulation: Upregulates over 300 genes associated with tissue repair, angiogenesis, and antioxidant defense, while suppressing genes linked to inflammation and carcinogenesis.
Hair Growth Stimulation: Activates hair follicle stem cells and improves dermal papilla vascularization, promoting anagen phase transition in hair follicles.
📊 Research Applications
Dermatology: Studies on photoaging reversal, scar remodeling, and post-inflammatory hyperpigmentation.
Wound Healing: Preclinical models of ischemic ulcers, radiation-induced skin damage, and diabetic wound repair.
Cosmetic Science: Efficacy evaluation in anti-aging formulations (serums, creams, dermal fillers) for collagen synthesis and wrinkle reduction.
Regenerative Medicine: Investigation of tissue engineering scaffolds functionalized with GHK-Cu for skin and cartilage regeneration.
Trichology: Research on androgenetic alopecia and hair follicle miniaturization reversal.
💡 Product Features
Stability: Lyophilized form stable for 24 months at 2-8°C under dry,避光 conditions; reconstituted solutions (pH 5.5-7.0) stable for 7-14 days refrigerated.
Bioactivity: Induces collagen synthesis at nanomolar concentrations (EC₅₀ ~10 nM) with minimal cytotoxicity.
Synergistic Compatibility: Enhances efficacy when combined with hyaluronic acid, vitamin C, or growth factors (e.g., EGF, FGF) in cosmeceutical formulations.
Colorimetric Properties: Blue-purple hue serves as a natural indicator of copper complex stability; discoloration indicates copper ion dissociation.
⚠️ Disclaimer
For Research Use Only: Not approved for human clinical applications. Avoid mixing with strong acids/chelators (e.g., EDTA) that may disrupt copper coordination. Handle with standard peptide safety protocols, including proper reconstitution in sterile aqueous buffers.
None of our HGH lines are inherently better than the other. Each batch comes with a corresponding test report. Purity and dimer can be a decent proxy for “quality”, you want purity as high as possible and dimer as low as possible. The main factor to consider in our opinion, is the price per IU. Supreme is usually the best bang for buck option. Historically, Supreme & Deluxe have shown lower dimer content, although this may not always be the case, so of course reference the corresponding test reports.
For HGH, we typically recommend 1ml for every ~10 IU in the vial. If a batch tests at an average of 290 IU per kit, that is an average of 29 IU per vial, and we’d recommend 2.9ml of bacteriostatic water. This will make the syringe math similar to a traditional 100 iu kit with 1ml of solution For peptide reconstituion, you can use our amazing Dosage Calculator.
Not necessarily. If you look through all our lab reports, particularly the ones with multiple test reports in a single batch, you will see that the intra-batch variance can actually be quite high. When you purchase a batch, you can expect some of the vials in your kit to be as much as 5-15% +/- whatever the corresponding lab test reflects. This is simply the reality of product that is not made to the same standards as pharmaceutical grade growth hormone. To state otherwise would be disingenous. There can also be a high variance in the dimer content intra-batch. (For Example: Economy B, Deluxe A, etc) Over time, we’ve increased the volume of samples analyzed for each batch, to provide more transparancy regarding the potential for intra-batch variance. If you use the average IU figure provided on each product, your dosage should average out over time, so don’t overthink your administration protocol too much. We know it can be a bit overwhelming with all the different numbers provided. That said, don’t hesitate to reach out if you need specific guidance on dosage or reconstitution.
Yes! We offer store credit for quantitative testing of total IU/Purity (ie Janoshik testing), and for personal IGF-1 test results. Please email for more information. *TERMS APPLY*
Depending on your location, most customers receive their order in 2-10 business days. We ship with USPS Ground Shipping, from the United States only. 99% of orders ship within 24 hours (excluding weekends & holidays)
We are no longer providing tracking. If your order is over 10 business days old and hasn’t arrived, our customer service team can check your tracking information to see the status of your package
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Unfortunately we do not provide reships for incorrect addresses. In the VERY rare instance that a package is lost in transit, we will reship your order free of charge.
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