Product Category: Research-Grade Multi-Peptide Formulation Composition: Lyophilized blend of two metabolic peptides:
Cagrilintide: 5mg (Amylin analogue; CAS 1415456-99-3)
Semaglutide: 5mg (GLP-1 receptor agonist; CAS 910463-68-2) Physical Form: White to off-white sterile powder; reconstituted with 1-2mL sterile saline for injection. Storage: Stable at -20°C for 24 months; refrigerate (2-8°C) after reconstitution and use within 5 days. Manufacturer: Available through specialized peptide suppliers (e.g., Shenzhen Aoxi Technology, Hubei Zhaoke Bio-Chemical) with purity ≥99% (HPLC verified).
🔬 Mechanism of Synergistic Action
🌀 Cagrilintide (5mg): Amylin Analogue
Central Satiety Regulation: Activates amylin receptors in the area postrema, suppressing appetite by enhancing meal termination signals (complementary to GLP-1’s hypothalamic action).
Metabolic Cross-Talk: Upregulates brown adipose tissue thermogenesis via AMPK phosphorylation, increasing energy expenditure independently of caloric restriction.
🌀 Semaglutide (5mg): GLP-1 Receptor Agonist
Appetite Suppression: Stimulates GLP-1R in the arcuate nucleus, reducing hunger signals and food intake via POMC neuron activation.
Glycemic Control: Enhances insulin secretion in a glucose-dependent manner; reduces hepatic glucose production.
Gastrointestinal Effects: Delays gastric emptying to prolong satiety, with additional benefits for gut microbiota modulation.
📈 Synergistic Interactions
The combination leverages non-overlapping mechanisms to amplify weight loss:
Energy Balance Reset: Cagrilintide’s thermogenic effect complements Semaglutide’s caloric reduction, addressing both intake and expenditure.
Reduced Tolerance Development: Preclinical data suggests combined therapy may mitigate receptor desensitization observed with long-term GLP-1 monotherapy.
🧪 Research Applications & Preclinical Data
This formulation is primarily used in experimental settings to investigate:
Obesity Pharmacology: Evaluation of combined peptide effects on body weight regulation and metabolic parameters.
Synergy Studies: Mechanistic research on amylin-GLP-1 cross-talk in animal models (e.g., DIO mice, non-human primates).
Dose Optimization: Assessment of 5mg:5mg ratio efficacy compared to other combinations (e.g., 2.4mg Semaglutide + 2.4mg Cagrilintide in clinical trials).
Key Preclinical Findings (from related CagriSema trials):
In DIO mice, combination therapy reduced body weight by 28% vs. 15% with Semaglutide alone and 12% with Cagrilintide alone (12-week treatment).
Improved glycemic control: HbA1c reduction of 1.8% vs. 1.1% (Semaglutide monotherapy) in diabetic rodent models.
⚠️ Safety & Handling
Research Use Only (RUO): Not approved for human or veterinary clinical use; intended for in vitro and in vivo studies.
Adverse Event Profile: Expected transient gastrointestinal effects (nausea, diarrhea) based on individual peptide properties; requires dose-escalation protocols in animal models.
Reconstitution: Dissolve in sterile 0.9% NaCl; avoid vigorous shaking to prevent peptide denaturation.
📊 Comparative Efficacy (Related Clinical Data)
While direct data for the 5mg+5mg formulation is limited, the clinical candidate CagriSema (Semaglutide 2.4mg + Cagrilintide 2.4mg) demonstrated:
Phase II Results: 15.6% mean weight loss at 32 weeks vs. 5.1% (Semaglutide alone) and 8.1% (Cagrilintide alone) in obese adults (p<0.001).
Responder Rates: 63% achieved ≥15% weight loss vs. 12% with Semaglutide monotherapy.
None of our HGH lines are inherently better than the other. Each batch comes with a corresponding test report. Purity and dimer can be a decent proxy for “quality”, you want purity as high as possible and dimer as low as possible. The main factor to consider in our opinion, is the price per IU. Supreme is usually the best bang for buck option. Historically, Supreme & Deluxe have shown lower dimer content, although this may not always be the case, so of course reference the corresponding test reports.
For HGH, we typically recommend 1ml for every ~10 IU in the vial. If a batch tests at an average of 290 IU per kit, that is an average of 29 IU per vial, and we’d recommend 2.9ml of bacteriostatic water. This will make the syringe math similar to a traditional 100 iu kit with 1ml of solution For peptide reconstituion, you can use our amazing Dosage Calculator.
Not necessarily. If you look through all our lab reports, particularly the ones with multiple test reports in a single batch, you will see that the intra-batch variance can actually be quite high. When you purchase a batch, you can expect some of the vials in your kit to be as much as 5-15% +/- whatever the corresponding lab test reflects. This is simply the reality of product that is not made to the same standards as pharmaceutical grade growth hormone. To state otherwise would be disingenous. There can also be a high variance in the dimer content intra-batch. (For Example: Economy B, Deluxe A, etc) Over time, we’ve increased the volume of samples analyzed for each batch, to provide more transparancy regarding the potential for intra-batch variance. If you use the average IU figure provided on each product, your dosage should average out over time, so don’t overthink your administration protocol too much. We know it can be a bit overwhelming with all the different numbers provided. That said, don’t hesitate to reach out if you need specific guidance on dosage or reconstitution.
Yes! We offer store credit for quantitative testing of total IU/Purity (ie Janoshik testing), and for personal IGF-1 test results. Please email for more information. *TERMS APPLY*
Depending on your location, most customers receive their order in 2-10 business days. We ship with USPS Ground Shipping, from the United States only. 99% of orders ship within 24 hours (excluding weekends & holidays)
We are no longer providing tracking. If your order is over 10 business days old and hasn’t arrived, our customer service team can check your tracking information to see the status of your package
If your order was marked as “completed”, typically this means a label has been generated and your order is scheduled to go out that day or the next. “Processing” status orders have not been shipped, processing means payment has been confirmed successfully. Don’t hesitate to reach out regarding the status of your order.
Unfortunately we do not provide reships for incorrect addresses. In the VERY rare instance that a package is lost in transit, we will reship your order free of charge.
Semaglutide is a GLP-1 receptor agonist originally developed for type 2 diabetes and now widely used in medically guided weight loss and metabolic optimization protocols. By mimicking the natural hormone GLP-1, it helps regulate blood sugar, reduce appetite, and delay gastric emptying — resulting in sustained fat loss, improved insulin sensitivity, and enhanced satiety.
This product contains Semaglutide in lyophilized (freeze-dried) powder form, requiring reconstitution before use.
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Tirzepatide is a cutting-edge dual incretin agonist that mimics both GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) — two key hormones involved in regulating blood sugar, satiety, and energy balance. This unique mechanism allows for enhanced appetite suppression, improved insulin sensitivity, and significant fat loss when combined with proper nutrition and lifestyle protocols.
Available as a lyophilized powder, Tirzepatide requires reconstitution prior to use.
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This product has multiple variants. The options may be chosen on the product page
