Alprostadil is an endogenous prostaglandin E1 (PGE1) with a cyclopentane ring structure and two hydroxyl groups at C-11 and C-15. As a white to off-white crystalline powder, it is practically insoluble in water but soluble in ethanol and chloroform. Pharmaceutical formulations include injectable solutions (5-10μg/mL in lipid microspheres for targeted delivery), urethral suppositories (125-1000μg), and cream preparations (0.25g:1mg). The lipid microsphere-encapsulated form enhances stability and tissue targeting, allowing rapid vascular uptake while minimizing systemic side effects.
⚙️ Mechanism of Action
Vasodilation: Activates adenylate cyclase, increasing intracellular cAMP levels to relax vascular smooth muscle—particularly in microvasculature and erectile tissue. This action improves blood flow in ischemic limbs and promotes penile tumescence by dilating cavernosal arteries.
Antiplatelet Activity: Inhibits platelet aggregation via cAMP-mediated reduction of thromboxane A2 synthesis, preventing thrombus formation in transplant vasculature and occlusive arterial disease.
Smooth Muscle Relaxation: Directly relaxes bronchial, gastrointestinal, and uterine smooth muscle, though clinical use primarily leverages vascular effects.
Cellular Protection: Stabilizes lysosomal membranes and reduces inflammatory cytokine release in chronic liver disease models.
📊 Clinical Applications
Indication
Formulation
Dosage
Clinical Efficacy
Chronic Arterial Occlusion
IV Injection (5-10μg/day)
1-2mL diluted in 10mL saline, slow IV push or infusion qd for 2-4 weeks
Improves rest pain (70% response rate) and promotes ulcer healing (55% closure at 8 weeks)
Erectile Dysfunction
Urethral Suppository (125-1000μg)
Intracavitary administration 5-20 minutes pre-coitus; max 1 dose/24h
Achieves adequate erections in 65-75% of patients; onset 5-10 minutes, duration 30-60 minutes
Neonatal Arterial Duct Dependence
IV Infusion (5-100ng/kg/min)
Titrated to maintain ductal patency until surgical correction
Maintains oxygenation in 80% of critical congenital heart disease cases
Organ Transplantation
IV Injection (10-20μg/kg/day)
Added to preservation solution or post-op infusion to prevent microthrombosis
Reduces graft failure by 35% in renal transplant recipients
Chronic Hepatitis
IV Injection (10μg/day)
Adjunctive therapy for 4-8 weeks
Improves ALT/AST levels in 40% of non-viral hepatitis patients
Contraindications: Severe heart failure, pregnancy, hypersensitivity to prostaglandins, and conditions predisposing to priapism (e.g., sickle cell anemia).
Precautions: Use with caution in glaucoma (may increase intraocular pressure), peptic ulcer disease (risk of bleeding), and pulmonary edema.
💊 Pharmacokinetics
Absorption: Rapid uptake via intravenous (100% bioavailability) or intraurethral (80% absorption within 10 minutes) routes; topical cream shows 3-5% systemic absorption.
Metabolism: 60-90% cleared by pulmonary first-pass metabolism to inactive 15-keto-PGE1; plasma half-life: 2-5 minutes.
Excretion: 90% of metabolites excreted in urine within 24 hours; minimal biliary elimination.
None of our HGH lines are inherently better than the other. Each batch comes with a corresponding test report. Purity and dimer can be a decent proxy for “quality”, you want purity as high as possible and dimer as low as possible. The main factor to consider in our opinion, is the price per IU. Supreme is usually the best bang for buck option. Historically, Supreme & Deluxe have shown lower dimer content, although this may not always be the case, so of course reference the corresponding test reports.
For HGH, we typically recommend 1ml for every ~10 IU in the vial. If a batch tests at an average of 290 IU per kit, that is an average of 29 IU per vial, and we’d recommend 2.9ml of bacteriostatic water. This will make the syringe math similar to a traditional 100 iu kit with 1ml of solution For peptide reconstituion, you can use our amazing Dosage Calculator.
Not necessarily. If you look through all our lab reports, particularly the ones with multiple test reports in a single batch, you will see that the intra-batch variance can actually be quite high. When you purchase a batch, you can expect some of the vials in your kit to be as much as 5-15% +/- whatever the corresponding lab test reflects. This is simply the reality of product that is not made to the same standards as pharmaceutical grade growth hormone. To state otherwise would be disingenous. There can also be a high variance in the dimer content intra-batch. (For Example: Economy B, Deluxe A, etc) Over time, we’ve increased the volume of samples analyzed for each batch, to provide more transparancy regarding the potential for intra-batch variance. If you use the average IU figure provided on each product, your dosage should average out over time, so don’t overthink your administration protocol too much. We know it can be a bit overwhelming with all the different numbers provided. That said, don’t hesitate to reach out if you need specific guidance on dosage or reconstitution.
Yes! We offer store credit for quantitative testing of total IU/Purity (ie Janoshik testing), and for personal IGF-1 test results. Please email for more information. *TERMS APPLY*
Depending on your location, most customers receive their order in 2-10 business days. We ship with USPS Ground Shipping, from the United States only. 99% of orders ship within 24 hours (excluding weekends & holidays)
We are no longer providing tracking. If your order is over 10 business days old and hasn’t arrived, our customer service team can check your tracking information to see the status of your package
If your order was marked as “completed”, typically this means a label has been generated and your order is scheduled to go out that day or the next. “Processing” status orders have not been shipped, processing means payment has been confirmed successfully. Don’t hesitate to reach out regarding the status of your order.
Unfortunately we do not provide reships for incorrect addresses. In the VERY rare instance that a package is lost in transit, we will reship your order free of charge.
Semaglutide is a GLP-1 receptor agonist originally developed for type 2 diabetes and now widely used in medically guided weight loss and metabolic optimization protocols. By mimicking the natural hormone GLP-1, it helps regulate blood sugar, reduce appetite, and delay gastric emptying — resulting in sustained fat loss, improved insulin sensitivity, and enhanced satiety.
This product contains Semaglutide in lyophilized (freeze-dried) powder form, requiring reconstitution before use.
Select options
This product has multiple variants. The options may be chosen on the product page
MOTS-c is a naturally occurring mitochondrial-derived peptide that plays a key role in cellular energy regulation, fat metabolism, and glucose control. Often referred to as a “metabolic mini-hormone,” MOTS-c enhances the body’s ability to burn fat, improve insulin sensitivity, and adapt to metabolic stress — making it an ideal peptide for those seeking fat loss, improved endurance, and anti-aging support.
This product is supplied as a lyophilized powder and requires reconstitution prior to subcutaneous injection.
Select options
This product has multiple variants. The options may be chosen on the product page
