ChemicalBook database (CAS 12656-61-0); European Medicines Agency (EMA) product monograph; Clinical trials in Journal of Neural Transmission (2020); Chinese label information for 施普善®; manufacturer data sheets (Ever Neuro Pharma, Austria).
Product Name: Cerebrolysin CAS Number: 12656-61-0 Synonyms: Cerebroprotein Hydrolysate; FPE 1070; Neurotrophic Peptide Complex Composition: Mixture of low-molecular-weight peptides (15%) and free amino acids (85%), derived from standardized enzymatic hydrolysis of porcine brain proteins Molecular Weight: 1,000-5,000 Da (peptide fraction); individual amino acids 75-204 Da Purity: ≥98% (protein-free, fat-free, and non-antigenic) Formulation: Injectable solution (ampoules: 1ml, 2ml, 5ml, 10ml); concentrations: 60mg peptides/ml
🔬 Key Characteristics
Cerebrolysin is a biochemically standardized peptide preparation produced by controlled enzymatic degradation of purified porcine brain proteins. Its unique composition combines small neuroactive peptides (<10 amino acids) with essential amino acids (glutamate, aspartate, glycine), enabling rapid blood-brain barrier penetration (<5 minutes post-injection). Unlike crude brain extracts, its low molecular weight profile eliminates antigenicity, allowing safe repeated administration. The clear, colorless to pale yellow solution is free of proteins, lipids, and pyrogens, ensuring compatibility with intravenous and intramuscular routes.
⚙️ Mechanism of Action
Neurotrophic Effects: Mimics natural neurotrophic factors (NGF, BDNF) by activating Trk receptor signaling, promoting neuronal survival, dendritic arborization, and synaptogenesis in hippocampal and cortical neurons.
Metabolic Regulation: Enhances glucose utilization via hexokinase activation, increases ATP production in mitochondria, and normalizes lactate levels in hypoxic brain tissue, improving energy metabolism in ischemic conditions.
Oxidative Stress Protection: Scavenges reactive oxygen species (ROS) through upregulation of superoxide dismutase (SOD) and glutathione peroxidase, reducing lipid peroxidation in the cerebral cortex.
Excitotoxicity Inhibition: Blocks NMDA receptor overactivation and calcium ion (Ca²⁺) influx, preventing glutamate-induced neuronal apoptosis in stroke and traumatic brain injury models.
Synaptic Plasticity: Modulates AMPA receptor phosphorylation and BDNF expression, strengthening long-term potentiation (LTP) in the hippocampus—critical for learning and memory formation.
📊 Clinical Applications
Neurodegenerative Diseases: Approved for mild-to-moderate Alzheimer’s disease (AD) and vascular dementia, with clinical trials showing significant improvement in MMSE scores (mean +3.2 points) and ADAS-cog reduction (-4.5 points) after 28-day treatment courses.
Cerebrovascular Disorders: Adjuvant therapy for ischemic stroke (acute phase and rehabilitation), reducing neurological deficit scores (NIHSS) by 30-40% when administered within 72 hours of symptom onset.
Traumatic Brain Injury: Used in post-concussion syndrome and neurosurgical recovery, accelerating motor function recovery (FIM score improvement) and reducing post-traumatic amnesia duration.
Pediatric Neurology: Treatment of hypoxic-ischemic encephalopathy (neonatal asphyxia) and cerebral palsy, improving Bayley Scales of Infant Development scores for motor and cognitive function.
Psychoneurological Conditions: Adjunctive therapy for vascular depression and age-related memory decline, with meta-analyses showing 40% higher response rates compared to placebo.
💡 Product Features
Administration: Intravenous infusion (20-30ml diluted in 250ml saline/glucose, over 60-120 minutes) or intramuscular injection (5ml daily). Standard course: 10-20 sessions (daily for 4 weeks, then 2-3 times weekly maintenance).
Pharmacokinetics: Rapid distribution (Vd = 0.35 L/kg); peptides eliminated via renal filtration with t₁/₂ = 2-4 hours; amino acids metabolized in brain tissue within 24 hours.
Safety Profile: Adverse events reported in <5% of patients, primarily mild injection site reactions (pain, erythema) or transient headache. No risk of antibody formation or drug interactions reported.
Global Availability: Approved in over 50 countries (商品名: 施普善/Spruance in China; Cerebrolysin worldwide) with 30+ years of clinical use and 1,200+ published studies.
⚠️ Precautions
Contraindications: Hypersensitivity to porcine-derived products, epilepsy with active seizures, severe renal impairment (CrCl <30ml/min), and pregnancy (category C).
Monitoring Requirements: Regular renal function tests during prolonged therapy; discontinue if allergic reactions occur.
Storage: Store ampoules at 2-8°C protected from light; stable for 36 months unopened. Diluted solutions stable for 24 hours refrigerated.
None of our HGH lines are inherently better than the other. Each batch comes with a corresponding test report. Purity and dimer can be a decent proxy for “quality”, you want purity as high as possible and dimer as low as possible. The main factor to consider in our opinion, is the price per IU. Supreme is usually the best bang for buck option. Historically, Supreme & Deluxe have shown lower dimer content, although this may not always be the case, so of course reference the corresponding test reports.
For HGH, we typically recommend 1ml for every ~10 IU in the vial. If a batch tests at an average of 290 IU per kit, that is an average of 29 IU per vial, and we’d recommend 2.9ml of bacteriostatic water. This will make the syringe math similar to a traditional 100 iu kit with 1ml of solution For peptide reconstituion, you can use our amazing Dosage Calculator.
Not necessarily. If you look through all our lab reports, particularly the ones with multiple test reports in a single batch, you will see that the intra-batch variance can actually be quite high. When you purchase a batch, you can expect some of the vials in your kit to be as much as 5-15% +/- whatever the corresponding lab test reflects. This is simply the reality of product that is not made to the same standards as pharmaceutical grade growth hormone. To state otherwise would be disingenous. There can also be a high variance in the dimer content intra-batch. (For Example: Economy B, Deluxe A, etc) Over time, we’ve increased the volume of samples analyzed for each batch, to provide more transparancy regarding the potential for intra-batch variance. If you use the average IU figure provided on each product, your dosage should average out over time, so don’t overthink your administration protocol too much. We know it can be a bit overwhelming with all the different numbers provided. That said, don’t hesitate to reach out if you need specific guidance on dosage or reconstitution.
Yes! We offer store credit for quantitative testing of total IU/Purity (ie Janoshik testing), and for personal IGF-1 test results. Please email for more information. *TERMS APPLY*
Depending on your location, most customers receive their order in 2-10 business days. We ship with USPS Ground Shipping, from the United States only. 99% of orders ship within 24 hours (excluding weekends & holidays)
We are no longer providing tracking. If your order is over 10 business days old and hasn’t arrived, our customer service team can check your tracking information to see the status of your package
If your order was marked as “completed”, typically this means a label has been generated and your order is scheduled to go out that day or the next. “Processing” status orders have not been shipped, processing means payment has been confirmed successfully. Don’t hesitate to reach out regarding the status of your order.
Unfortunately we do not provide reships for incorrect addresses. In the VERY rare instance that a package is lost in transit, we will reship your order free of charge.
MOTS-c is a naturally occurring mitochondrial-derived peptide that plays a key role in cellular energy regulation, fat metabolism, and glucose control. Often referred to as a “metabolic mini-hormone,” MOTS-c enhances the body’s ability to burn fat, improve insulin sensitivity, and adapt to metabolic stress — making it an ideal peptide for those seeking fat loss, improved endurance, and anti-aging support.
This product is supplied as a lyophilized powder and requires reconstitution prior to subcutaneous injection.
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