Tesamorelin is a synthetic analog of human growth hormone-releasing hormone (GHRH) featuring an N-terminal trans-3-hexenoyl fatty acid modification. This lipophilic moiety enhances metabolic stability and prolongs half-life (~2 hours) compared to native GHRH, enabling sustained growth hormone (GH) secretion in preclinical models. Originally developed as TH9507, its 44-amino acid sequence retains the full biological activity of endogenous GHRH while resisting enzymatic degradation through structural optimization.
⚙️ Mechanism of Action
GHRH Receptor Agonism: Binds to pituitary GHRH receptors, activating adenylate cyclase and cAMP signaling to stimulate pulsatile GH release.
Lipophilic Modification: The trans-3-hexenoyl group increases plasma protein binding, reducing renal clearance and extending systemic exposure.
IGF-1 Mediation: Induces downstream insulin-like growth factor-1 (IGF-1) production, promoting anabolic effects on muscle, bone, and metabolism.
Minimal Desensitization: Sustained but physiological GH secretion avoids pituitary receptor downregulation seen with continuous GHRH exposure.
📊 Research Applications
Endocrinology: Studies on GH deficiency, somatotropic axis regulation, and age-related hormonal decline.
Metabolic Research: Investigation of visceral fat reduction, insulin sensitivity, and lipid metabolism in obesity models.
Clinical Translation: Preclinical evaluation for growth disorders, sarcopenia, and HIV-associated lipodystrophy.
Pharmacokinetic Studies: Analysis of fatty acid-modified peptides for optimized drug delivery and half-life extension.
💡 Product Features
Stability: Lyophilized form stable for 24 months at 2-8°C; reconstituted solutions (sterile saline) stable for 72 hours under refrigeration.
Bioactivity: Specific activity ≥5.0×10⁴ IU/mg (rat pituitary cell GH release assay), with ED₅₀ ≤10 nM.
Selectivity: High affinity for GHRH receptors (Kd ~0.3 nM) with minimal cross-reactivity to other hypothalamic receptors.
Formulation Flexibility: Available as lyophilized powder or pre-formulated solutions for in vitro and in vivo research applications.
⚠️ Disclaimer
For Research Use Only: Not approved for human or veterinary clinical applications. Handling requires compliance with peptide research protocols, including proper reconstitution, storage, and biosafety measures.
None of our HGH lines are inherently better than the other. Each batch comes with a corresponding test report. Purity and dimer can be a decent proxy for “quality”, you want purity as high as possible and dimer as low as possible. The main factor to consider in our opinion, is the price per IU. Supreme is usually the best bang for buck option. Historically, Supreme & Deluxe have shown lower dimer content, although this may not always be the case, so of course reference the corresponding test reports.
For HGH, we typically recommend 1ml for every ~10 IU in the vial. If a batch tests at an average of 290 IU per kit, that is an average of 29 IU per vial, and we’d recommend 2.9ml of bacteriostatic water. This will make the syringe math similar to a traditional 100 iu kit with 1ml of solution For peptide reconstituion, you can use our amazing Dosage Calculator.
Not necessarily. If you look through all our lab reports, particularly the ones with multiple test reports in a single batch, you will see that the intra-batch variance can actually be quite high. When you purchase a batch, you can expect some of the vials in your kit to be as much as 5-15% +/- whatever the corresponding lab test reflects. This is simply the reality of product that is not made to the same standards as pharmaceutical grade growth hormone. To state otherwise would be disingenous. There can also be a high variance in the dimer content intra-batch. (For Example: Economy B, Deluxe A, etc) Over time, we’ve increased the volume of samples analyzed for each batch, to provide more transparancy regarding the potential for intra-batch variance. If you use the average IU figure provided on each product, your dosage should average out over time, so don’t overthink your administration protocol too much. We know it can be a bit overwhelming with all the different numbers provided. That said, don’t hesitate to reach out if you need specific guidance on dosage or reconstitution.
Yes! We offer store credit for quantitative testing of total IU/Purity (ie Janoshik testing), and for personal IGF-1 test results. Please email for more information. *TERMS APPLY*
Depending on your location, most customers receive their order in 2-10 business days. We ship with USPS Ground Shipping, from the United States only. 99% of orders ship within 24 hours (excluding weekends & holidays)
We are no longer providing tracking. If your order is over 10 business days old and hasn’t arrived, our customer service team can check your tracking information to see the status of your package
If your order was marked as “completed”, typically this means a label has been generated and your order is scheduled to go out that day or the next. “Processing” status orders have not been shipped, processing means payment has been confirmed successfully. Don’t hesitate to reach out regarding the status of your order.
Unfortunately we do not provide reships for incorrect addresses. In the VERY rare instance that a package is lost in transit, we will reship your order free of charge.
Semaglutide is a GLP-1 receptor agonist originally developed for type 2 diabetes and now widely used in medically guided weight loss and metabolic optimization protocols. By mimicking the natural hormone GLP-1, it helps regulate blood sugar, reduce appetite, and delay gastric emptying — resulting in sustained fat loss, improved insulin sensitivity, and enhanced satiety.
This product contains Semaglutide in lyophilized (freeze-dried) powder form, requiring reconstitution before use.
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$110.00–$455.00Price range: $110.00 through $455.00
