Product Name: CJC-1295 without DAC (Modified GRF 1-29) CAS Number: 863288-34-0 Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂ Molecular Weight: 3367.89 g/mol Amino Acid Sequence: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂ Purity: ≥98% (HPLC verified) Formulation: Lyophilized white powder (standard vials: 5mg, 10mg, or custom specifications)
🔬 Key Characteristics
CJC-1295 without DAC is a synthetic analog of growth hormone-releasing hormone (GHRH), specifically engineered as a modified version of GRF (1-29) with enhanced stability. Unlike its counterpart CJC-1295 with DAC (Drug Affinity Complex), this variant lacks the plasma protein-binding moiety, resulting in a shorter half-life (~30 minutes) and pulsatile growth hormone (GH) secretion profile. Its structure includes D-amino acid substitutions (e.g., D-Ala) to resist enzymatic degradation, ensuring improved bioavailability in preclinical models.
⚙️ Mechanism of Action
GHRH Receptor Agonism: Binds to GHRH receptors in the anterior pituitary gland, stimulating cyclic AMP (cAMP) signaling and calcium influx to trigger GH release in a dose-dependent manner.
Pulsatile Secretion: Induces physiological GH pulses similar to endogenous secretion patterns, avoiding desensitization of pituitary somatotrophs compared to continuous GH exposure.
IGF-1 Mediation: Promotes hepatic synthesis of insulin-like growth factor-1 (IGF-1), the primary mediator of GH’s anabolic effects on muscle, bone, and metabolism.
📊 Research Applications
Endocrinology: Studies on GH axis regulation, pituitary function, and age-related GH decline models.
Metabolic Research: Investigation of lean muscle preservation, fat oxidation, and insulin sensitivity in metabolic disorder models.
Comparative Pharmacology: Contrast studies with CJC-1295 with DAC to evaluate half-life effects on GH/IGF-1 dynamics.
Peptide Synergy: Combined use with GHRPs (e.g., Ipamorelin) to amplify GH secretion for enhanced anabolic or neuroprotective research outcomes.
💡 Product Features
Stability: Lyophilized form stable for 24 months at 2-8°C under dry,避光 conditions; reconstitutes in sterile aqueous solvents (e.g., bacteriostatic water).
Purity: ≥98% HPLC purity with low endotoxin levels (<10 EU/mg), suitable for in vitro and in vivo research.
Pharmacokinetic Profile: Short-acting nature enables precise control over GH secretion timing in time-course experiments.
⚠️ Disclaimer
For Research Use Only: Not approved for human or veterinary clinical applications. Handling requires adherence to peptide research protocols, including proper reconstitution, storage, and biosafety measures.
None of our HGH lines are inherently better than the other. Each batch comes with a corresponding test report. Purity and dimer can be a decent proxy for “quality”, you want purity as high as possible and dimer as low as possible. The main factor to consider in our opinion, is the price per IU. Supreme is usually the best bang for buck option. Historically, Supreme & Deluxe have shown lower dimer content, although this may not always be the case, so of course reference the corresponding test reports.
For HGH, we typically recommend 1ml for every ~10 IU in the vial. If a batch tests at an average of 290 IU per kit, that is an average of 29 IU per vial, and we’d recommend 2.9ml of bacteriostatic water. This will make the syringe math similar to a traditional 100 iu kit with 1ml of solution For peptide reconstituion, you can use our amazing Dosage Calculator.
Not necessarily. If you look through all our lab reports, particularly the ones with multiple test reports in a single batch, you will see that the intra-batch variance can actually be quite high. When you purchase a batch, you can expect some of the vials in your kit to be as much as 5-15% +/- whatever the corresponding lab test reflects. This is simply the reality of product that is not made to the same standards as pharmaceutical grade growth hormone. To state otherwise would be disingenous. There can also be a high variance in the dimer content intra-batch. (For Example: Economy B, Deluxe A, etc) Over time, we’ve increased the volume of samples analyzed for each batch, to provide more transparancy regarding the potential for intra-batch variance. If you use the average IU figure provided on each product, your dosage should average out over time, so don’t overthink your administration protocol too much. We know it can be a bit overwhelming with all the different numbers provided. That said, don’t hesitate to reach out if you need specific guidance on dosage or reconstitution.
Yes! We offer store credit for quantitative testing of total IU/Purity (ie Janoshik testing), and for personal IGF-1 test results. Please email for more information. *TERMS APPLY*
Depending on your location, most customers receive their order in 2-10 business days. We ship with USPS Ground Shipping, from the United States only. 99% of orders ship within 24 hours (excluding weekends & holidays)
We are no longer providing tracking. If your order is over 10 business days old and hasn’t arrived, our customer service team can check your tracking information to see the status of your package
If your order was marked as “completed”, typically this means a label has been generated and your order is scheduled to go out that day or the next. “Processing” status orders have not been shipped, processing means payment has been confirmed successfully. Don’t hesitate to reach out regarding the status of your order.
Unfortunately we do not provide reships for incorrect addresses. In the VERY rare instance that a package is lost in transit, we will reship your order free of charge.
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